(i) Listing of Research conducted Worldwide

1. Seriously weakened immune system
   
   

2. Genetic markers
   
   

3. Severely Damaged Mitochondria
   
   

4. A neurotoxin called Ciguatera discovered in Chronic Fatigue Syndrome
   
   

5. Abnormal adrenal glands & Abnormal HPA axis (Hypothalmus Pituary Adrenal axis)
   
   

6. Viral infections
   
   

7. Mycoplasma infections
   
   

8. Serious Bacteria infections
   
   

9. Abnormal red blood cell structure
   
   

10. Serious Brain abnormalities
    
    

11. Substance P is elevated in CFS / ME patients
    
    

12. Inability to metabolise glucose and sugar
    
    

13. Reduced acyl-carnitine. Carnitine is used in mitochondria oxydation.
    
    

14. Cardiac and Vascular problems. Increased risk of heart attack
    
    

15. Lowered oxygen consumption in ME / CFS patients
    
    

16. Effects of Exercise
    
    

17. Muscle damage
    
    

18. Thallium scans on ME/ CFS patients show serious abnormalities
    
    

19. Body fluid abnormalities
    
    

20. Disturbance in the way certain ions (mainly sodium and potassium salts) are transported in and out of cells across the cell membranes
    
    

21. Intestinal problems
    
    

22. Abnormal Plasma RNA's
    
    

23. Abnormal Urinary metabolites
    
    

24. Environmental Toxins and hazards
    
    

25. Sleep abnormalities
    
    

26. The presence of crimson crescents in the mouth
    
    

27. Beta 2 microglobulin levels as a measure of the severity of the condition
    
    

28. Abnormal levels of serum Chromogranin-A. Evidence of Celiac disease in some CFS patients
    
    

29. Skin rashes, acne and allergies worsen after the onset of CFS
    
    

30. Glutathione Deficiency
    
    

31. Increased oxidative stress
    
    

32. Increased risk of Cancer
    
    

33. Other Serious Abnormalities
    
    

34. Sub-groups within CFS
    
    

35. Scientific Analysis of the root causes and all of the Symptoms found in CFS